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Re: L-serine(FDA 승인) --> 글리신 대사.. neuroprotection 탐구!! 2024.08.27해당카페글 미리보기
producing reactive oxygen species that can initiate cell death while the M2 phenotype allows for repair through phagocytosis and anti-inflammatory factor production [15,16]. L-serine plays a role in the polarization of macrophages to...
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Re: 중추신경 대사 찌거기 제거 시스템.. 글림프계 glymphatic system!! 2024.08.22해당카페글 미리보기
the cellular volume fraction resulting in a decrease in the interstitial space [82]. In turn, the resistance toward convective exchange of CSF and ISF increases and this results in a suppression of glymphatic fluxes during wakefulness...
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Re: 다발성 경화증 B cell 자가면역 염증 ... 2022 nature 논문.. 2024.08.21해당카페글 미리보기
dependent cellular cytotoxicity but, instead, it is likely that these antibodies affect the crosslinking and internalization of NMDAR1. Thus, inflammation is not always required for B cells to be pathogenic. Autoantibody-driven pathology...
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Re: 성상교세포의 활성산소 대응 역할 .. 2020.. 2024.08.20해당카페글 미리보기
to reactive astrogliosis aggravating inflammation and glial scar formation, both of which burden the CNS. Increasing evidence indicates that astrocyte might be a promising target for oxidative stress modulation in CNS and this may...
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Re: 파킨슨 기전과 파킨슨 치료 천연물, 한약재 탐구...nature 2023 2024.08.20해당카페글 미리보기
overwhelms cellular antioxidant activity. Cytotoxic compounds then accumulate to cause protein collapse, enzyme failure, lipid breakdown,86 and cell death in various neurons, including DA-neuronal tissue (Fig. 2).87 These dysfunctions...
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neuron이 과부하가 걸리면? 신경세포의 과흥분성은 치매의 시작. 어떻게 알 수 있나? 2024.08.19해당카페글 미리보기
the cellular and molecular levels. Pluripotent stem cells can be differentiated into neurons in two-dimensional cultures; however, the lack of Aβ aggregates due to regular cell media change is one of the disadvantages that has been...
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타우린 인체에 가장 많은 유리 아미노산 뇌신경, 시신경 보호 기전 탐구!!! 2024.08.16해당카페글 미리보기
of reactive oxygen species (ROS) (Weiss et al., 1982). Similarly, taurine conjugates with a tRNA to enhance the expression of the nicotinamide adenine dinucleotide (NAD)-ubiquinone oxidoreductase chain 6, a subunit of the respiratory...
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Re: 파킨슨 병에서 미세아교세포의 역할 탐구 2022년 ... 2024.08.15해당카페글 미리보기
or cellular damage including neurodegeneration [27, 28]. The NLRP3 inflammasome pathway may be triggered by fibrillary α-synuclein (α-syn) or directly by dopaminergic cell death (elicited by the neurotoxin 6-hydroxidopamine) in the...
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Re: 파킨슨 병 .. 철분과 DMT divalent metal transporter !! 2024.08.15해당카페글 미리보기
for cellular transport of iron require DMT1 for the transport of iron. DMT1, also known as natural resistance associated macrophage protein 2 (Nramp2), is a widely expressed mammalian ferrous ion (Fe2+) transporter 3. Importantly, a...
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Re: 파킨슨 병 .. 철분 항상성 문제 2024 nature !! 2024.08.14해당카페글 미리보기
nucleic acid modifications [2]. All these molecular alterations ultimately compromise vital cellular functions and could lead to cell death. An increase in reactive oxygen species (ROS) that overpowers the antioxidant capacity of the...