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the epiphyseal surface of the femur on P0.13 Nerve growth factor (NGF), which supports neuronal survival and guides axonal growth, is expressed in perichondrial cells as early as E14.5.13 The requirement of TrkA signaling in sensory...

factors [10,11]. Likewise, the exploration of novel therapeutics, even combinatorial therapies, capable of enhancing axonal regeneration and promoting functional recovery, are of great interest. PNI often results in neuropathic pain, and...

When tau protein becomes highly phosphorylated, it aggregates, inhibiting microtubule function, impairing neuronal axonal transport, and thus leading to neuronal cytotoxicity84. Emerging evidence has suggested that in addition to A...

손상이 초래되어 오랜 기간 동안 의식이 회복되지 않을 수 있으며 이는 뇌진탕과 구별되는 미만성 축삭손상(Diffuse Axonal Injury)이라는 병명이 됩니다. 이 둘은 주로 두부에 가해진 직접적인 충격보다는 회전 관성(각가속)에 의해 초래되는 병변입니다...

하며 도파민을 분비하는 뇌 부위이다. 고령의 TPBG 유전자 결핍 생쥐 선조체는 도파민 신경섬유에서 축삭돌기 팽윤(axonal swelling/axonal spheroids)을 보이며 실제 도파민 농도가 정상 생쥐 대비 약 30% 감소했다. 이어서 연구팀은 파킨슨병 운동장애를...

can distinguish between the subtypes of GBS: acute inflammatory demyelinating polyradiculoneuropathy (AIDP), acute motor axonal neuropathy (AMAN) and acute motor sensory axonal neuropathy (AMSAN)5. Disease progression can be rapid, and...

As a result, early-life perturbations in the maturation of the microbiota can result in deficits in neurogenesis, axonal and dendritic growth and synaptogenesis, which can negatively impact on later mental health [4]. Indeed, compared to...

cells including neurons.71 Neurons are consisted of three distinct regions: soma, long axon and thick dendrites. Axonal transport, mitochondrial movement from soma to distal axonal, is driven by microtubule-anchored kinesin1 (also called...

Indeed, inhibition of the expression and functioning of glutamate transporters such as EAATs and xC-transporters in axonal tracts is sufficient to induce oligodendrocyte loss and demyelination, which undermines brain connectivity...