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DNAJB1), which stimulates ATPase activity, suggesting that to prevent aggregation the chaperones employ the same catalytic cycle that aids protein folding (Evans et al. 2006). Suppression of Aβ42 aggregation can also be achieved by sub...

As shown in Figs. 7a, b, P + M intoxication elevated the expression levels of p47phox and gp91phox, the cytosolic and catalytic subunit of NOX2, respectively, in midbrains of mice, which was significantly reduced by taurine. Consistent...

Nrf2-related proteins or protein subunits are NAD(P)H, heme oxygenase-1 (HO-1), dehydrogenase quinone 1 (NQO1), catalytic subunit (GCLC), and the γ-glutamyl cysteine ligase modulatory subunit (GCLM). It is also related to pro...

a common dysregulation of UPS and autophagy in etiologically different CNS disorders is rooted in their pleiotropic catalytic functions, which are seminal for both synaptic plasticity and neuro-immunity [30,78,79,80,81,82,83,84,85,86,87...