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fragilis toxin), colibactin(pks+ E. coli 등)이 DNA 손상과 세포 변형을 유발한다. 세균 대사산물: SCFA, 폴리아민, 2차 담즙산 등이 과다하거나 불균형해지면 염증·증식 신호를 촉진할 수 있다. 결과적으로 **상피·점막 장벽 손상(leaky gut)**이...

diphtheria toxin A (DTA) 발현 → 3일 만에 ICC 50% 이상 제거 ICC-specific Prkg1 (cGMP-dependent protein kinase I) knockout → NO-mediated 억제성 신호 연구 기능 평가: 장 통과 시간, 위장관 운동성, 전기 생리 기록(intracellular recording), ex...

cytolytic toxin produced by S. pyogenes. This streptolysin is essential for inhibiting neutrophil recruitment in the initial stages of S. pyogenes infection, as observed in studies using zebrafish [53]. Similarly, zinc metalloproteinase...

Tetanus toxin induces fusion and aggregation of lipid vesicles containing phosphatidylinositol at low pH". Biochemical and Biophysical Research Communications. 128 (2): 840–9. Bibcode:1985BBRC..128..840C. doi:10.1016/0006-291X(85)90123...

uremic toxin. In addition, it is reported that p-cresyl sulfate and indoxyl sulfate contribute to vascular calcification through mechanisms involving oxidative stress, inflammation, and the promotion of osteogenic differentiation in...

A, toxin gene/repressor, and up- and downstream homologous sequences of the target gene can be constructed as fragments or on a plasmid. Examples of selectable markers A include: cat (chloramphenicol), phleo (phleomycin), or spe...

occludens toxin (Zot, or zonulin)-mediated disengagement of the protein ZO-1 from the TJ protein complex16. Zonulin is secreted by intestinal epithelial cells following stimuli from diet or microbiota. We first assessed serum zonulin...

translation을 block하는 방법 ☞antisense oligonucleotide ④HIV에 감염된 세포를 조준공격 ☞Pseudomonas toxin을 실험실에서 만든 CD-4에 붙여서 유도미사일! 하지만 분자량이 커서 Blood-brain barrier를 통과못하며 생체내에서 무효 ⑤유전자이식 ⑥...

diphtheria toxin A (DTA) expression in PDGFRβ+ cells [35]. Currently it is not clear why loss of pericytes leads to different vascular barrier phenotypes in development and adulthood. Given that the BBB becomes functional during late...