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of chemotherapeutic agents such as carboplatin,103 cisplatin,104 and gemcitabine.105 Additionally, it regulates the citrate metabolism pathway in tumor cells, further sensitizing them to chemotherapeutic agents.106 For instance, in...

with control rats (Fig. 2a). We then measured the maximal activity of the respiratory chain complexes (I–IV) and citrate synthase, a mitochondrial matrix enzyme, in plantaris muscle homogenates (Fig. 2b). Complex I, III, and IV had...

TCA cycle flux contributes to ATP production via oxidative and substrate level phosphorylation. When matrix citrate levels rise, citrate is transported to the cytoplasm and yields acetyl-CoA, the starting material for synthesis of fatty...