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Re: 흉선 노화... 어떻게? 2025.05.03해당카페글 미리보기
leads to a gradual reduction in thymic cellularity and thymic stromal microenvironment disruption, including loss of definite cortical‐medullary junctions, reduction of cortical thymic epithelial cells and medullary thymic epithelial...
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면역관용 - central tolerance, peripheral tolerance , 조절 T세포 2026.05.17해당카페글 미리보기
cTEC (cortical TEC)에 의한 Positive selection: self-MHC를 인식하는 T 세포만 생존. 흉선 수질(Medulla): Single Positive (SP) T 세포 (CD4+ 또는 CD8+). mTEC가 Aire를 통해 TRA를 제시 → Negative selection: 강하게 자기반응성(autoreactive)인 T...
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Re: CSF 흐름, Meningeal lymphatic drainage, 최신 Neuroscience의 이해 2026.05.09해당카페글 미리보기
that disruption of mLVs located dorsal to the skull impairs CSF drainage and the migration of tumor cells to dCLNs, indicating their critical role in tumor-associated immune processes.64 This findings suggests that the structural...
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흔한 신경 포착 통증과 신경의 기능 탐구!! 2026.04.24해당카페글 미리보기
증상, cortical malformation 등. 긴 축삭을 가진 운동신경원(motor neurons)이 특히 취약. 다른 신경퇴행성 질환에서의 수송 장애: Alzheimer’s (tau, amyloid), ALS (TDP-43, SOD1), Parkinson 등에서 transport defect 관찰. Aging에서도 transport...
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뇌 소혈관질환 cerebral small vessel disease 네이처 리뷰 2025.12.23해당카페글 미리보기
network disruption by SVD can lead to clinical deficits. We address reserve and compensatory mechanisms in SVD and discuss the part played by other age-related pathologies. Finally, we conclude that SVD should be considered a global...
