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leads to a gradual reduction in thymic cellularity and thymic stromal microenvironment disruption, including loss of definite cortical‐medullary junctions, reduction of cortical thymic epithelial cells and medullary thymic epithelial...

cTEC (cortical TEC)에 의한 Positive selection: self-MHC를 인식하는 T 세포만 생존. 흉선 수질(Medulla): Single Positive (SP) T 세포 (CD4+ 또는 CD8+). mTEC가 Aire를 통해 TRA를 제시 → Negative selection: 강하게 자기반응성(autoreactive)인 T...

that disruption of mLVs located dorsal to the skull impairs CSF drainage and the migration of tumor cells to dCLNs, indicating their critical role in tumor-associated immune processes.64 This findings suggests that the structural...

증상, cortical malformation 등. 긴 축삭을 가진 운동신경원(motor neurons)이 특히 취약. 다른 신경퇴행성 질환에서의 수송 장애: Alzheimer’s (tau, amyloid), ALS (TDP-43, SOD1), Parkinson 등에서 transport defect 관찰. Aging에서도 transport...

network disruption by SVD can lead to clinical deficits. We address reserve and compensatory mechanisms in SVD and discuss the part played by other age-related pathologies. Finally, we conclude that SVD should be considered a global...

with disruption of the periosteum (Niv et al., 2003). In addition, patients often perceive bone pain in pathologies confined principally to the bone marrow that have no obvious periosteal involvement (e.g., intra-osseous engorgement...

mechanical disruption of the rotator cuff tendons, changes in the coracoacromial arch and osteophytes along the acromion in patients more than 40 years was Grade-3 [4]. The management plane of the shoulder impingement syndrome is...

controls. Cortical freeze injury gives rise to a significantly greater brain water content and higher ICP in AQP4-deficient mice. In a brain tumor edema model involving stereotactic implantation of melanoma cells, AQP4-deficient mice...

capsular disruption, shearing, fractures, infection, and arthritis.18 These etiologies can be acute or repetitive in nature.23 Historic risk factors and associations include scoliosis, lumbar fusion, pregnancy, seronegative HLA-B27...