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68]. Growth factors like FGF9 further promote HAS2 expression through activation of the Wnt/β-catenin/TCF7L2 pathway, a critical signaling axis involved in development, tissue homeostasis, and disease [69,70]. The Wnt/β-catenin pathway...

studies showed that the rhythmic activation of the Unfolded Protein Response (UPR), a signal transduction pathway adjusting critical cellular function to the accumulation of proteins inside the endoplasmic reticulum (ER)49, plays a...

a critical regulator of vascular homeostasis, neurotransmission and host defence27,28. NO is an autocrine and paracrine signalling molecule whose lifetime and diffusion gradients are limited by scavenging reactions involving haemoglobin...

of smad2/3 mediated by binding to vitamin D receptors in nasal polyp-derived fibroblasts Smad2/3 signaling is a critical pathway induced by TGF-β1. Smad2/3 phosphorylation and translocation into the nucleus regulate α-SMA and...

YAP (Yes-associated protein) and TAZ (Transcriptional coactivator with PDZ-binding motif), two critical effectors of the Hippo signaling pathway involved in cartilage homeostasis and mechanotransduction [88,89,90]. Through its...

with the proliferation and differentiation of ISCs and progenitors modulated by several critical signaling pathways. The Wnt-β-catenin pathway is pivotal for intestinal cell specification, enabling Wnt proteins, mostly secreted by...

12, 13]. BMAL1, in particular, is a key player in activating several pro-cancer pathways. One of the most critical is the c-Myc pathway, which regulates cell growth and division. Overexpression of c-Myc, driven by BMAL1, can lead to...

metabolic pathway to macrophage function and to determine whether one or more of the metabolic pathways can be targeted to improve ATM function in obesity. Other innate immune cells in AT Other populations of innate immune cells also...

monitoring critical information, dark hair tied back neatly with a headset and microphone positioned close to the mouth, wearing a modern camouflage military uniform with visible patches and structured fabric details, posture slightly...