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1. 5.1. Interactions among NFE2L2, p62/SQSTM1, and mTOR Pathways NFE2L2 signaling has been found to be a critical pathway that mediates autophagy and oxidative stress [66]. NFE2L2, also known as Nrf2, is a transcription factor that has...

treatment pathway to establish an algorithm for patients that can include conservative measures and interventional techniques once the diagnosis is identified. 소개: 천장관절(SIJ)은 요통의 38% 정도에서 통증의 원인이 되는 것으로 추정...

포식 활성화는 질병의 발병과 진행에 차별적인 영향을 미칠 수 있다고 합니다. AUTOPHAGY IN NEURONS Autophagy is a critical pathway to maintain homeostasis and to respond to cellular stress. The molecular components of the autophagy pathway...

changes in critical metabolites involved in bone biology From our previous study using plasma from AVNFH patient...matched control we have shown elevated levels of metabolites belonging to methionine-homocysteine pathway concomitant with...

are critical for the synthesis of this major cellular antioxidant. Accordingly, as glutathione concentrations can determine the response of tumours to therapy, xCT has been suggested as a putative therapeutic target.57,60,61 There is...

are critical for these tasks as they aid other proteins to fold correctly, to refold when reversibly denatured, to assemble into complexes, and to move to different cellular compartments. Finally, as a quality control mechanism...

a critical sensory deficit. Common autograft donors include the sural nerve, medial antebrachial cutaneous nerve, and lateral antebrachial cutaneous nerve, with the sural nerve offering up to 40 cm of graft length from each leg. 70 When...

a critical role in the progression of dopaminergic neurodegeneration in PD. The activation of microglia has long been observed in patients with PD, in which a vicious cycle formed between dys-regulated, over-activated microglia and...

Pain Pathway: Signals from events that may damage tissue (e.g. twisted joint, stressful impact) or from actual damaged tissue activate specialized sensory neurons known as nociceptors. Both bone and joint tissue are innervated by these...