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also account for lymphangiogenesis, an important route for tumor cells disseminating to regional lymph nodes and distant metastasis, in a VEGF-C (a ligand overexpressed by tumors)/VEGFR-3 (a receptor of VEGF-C expressed on the TAMs) axis...

cancer tissues was negatively correlated with the level of programmed death-1 ligand (PD-L1), the degree of distant metastasis, and lymphatic invasion of colorectal cancer. ZG16 overexpression in colon cancer cell lines (the SW480 and...

by upregulating the expression of matrix metalloproteinase 9 (MMP9), a mediating factor for local invasion and distant metastasis of tumors47. More recently, CRY1 has been suggested to be a critical factor for efficient DNA repair in...

burden in mice bearing melanoma,77 suggesting that NAPDH homeostasis represents therapeutic targets to impede distant metastasis. However, the association between MTHFD2L, which can use either NAD+ or NADP+ for dehydrogenase activity...