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by either refolding or degradation. The substrate specificity of Hsp70s in general is determined by specific J-domain family co-chaperones. Specific proteases can also associate with the mtHsp70 chaperone complex with the aid of reporter...

highly specific peptide substrates Z-Ala-Ala-Gln-pNA, Glp-Phe-Gln-pNA, and Glp-Phe-Gln-AMC, where Z is benzyloxycarbonyl, Glp—pyroglutamyl, pNa—p-nitroanilide, and AMC—4-amino-7-methylcoumaride [29,30,31]. Post-glutamine cleaving...

personnel from the University of California developed the Best Practices Matrix (Figure 1) that outlines domain-specific, age-appropriate characteristics of youth, applicable to 4-H programming. Anchored in similar work (McFarland et...

leading to an intracellular increase in cGMP concentration [8]. cGMP then binds to and modifies the target domain of specific proteins, including protein kinases, ion channels, and phosphodiesterases, to elicit cellular responses...