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of AD pathology. When tau protein becomes highly phosphorylated, it aggregates, inhibiting microtubule function, impairing neuronal axonal transport, and thus leading to neuronal cytotoxicity84. Emerging evidence has suggested that in...

several downstream signaling pathways including NF-κB5,41. ROS, especially H2O2 derived from activated NOX2 is capable of impairing NF-κB p50 function and then prolongs amplified M1 activation42. We recently reported that...

an oxidized cystine dimer. The xCT antiporter is inhibited by erastin, depleting the intracellular cysteine pool and impairing GSH production as a result. Another cellular antioxidant enzyme called DJ-1 prevents the transsulfuration...

with an increase in radiopacity, routine and straightforward use in dental exams, and noninvasive nature without impairing the bone healing process may aid in the reliable follow-up of ORNJ and other necrotic lesions (106, 107). Although...