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Key Contributor of Normal HA in the ECM The synthesis of HA is catalyzed by three hyaluronan synthase isoforms (HAS1, HAS2, and HAS3), among which HAS2 demonstrates unique regulatory properties and tissue-specific expression patterns...

each individual, but also the interindividual variability of phase. It would have been important to know what the volunteers were doing and when to determine whether their 12-h rhythms in gene expression were linked to behavioral...

핵심 contributor. Single-cell data로 organ origin 확인 → biological validity. 임상적 의미: Blood test로 장기별 aging acceleration 측정 → 조기 개입 타겟팅 가능 (e.g., accelerated kidney ager → metabolic intervention). 강조 숫자: Heart...

predominant contributor to disability worldwide. Core stability exercises (CSEs) serve as a common intervention; however, their therapeutic effects may be augmented through the incorporation of adjunct modalities such as neuromuscular...

major contributor [4]. It is known that prolonged sitting is detrimental to the maintenance of proper spinal alignment and stability, but mechanical loading of the spine during sitting and standing is still not well understood. A...

major contributor and a higher relative abundance of the phylum Firmicutes. As expected, these associations were strongest during the first 6 months of life and diminished thereafter. A major part of the maturation of the microbiota...

main contributor to the severe pain experienced by patients with OA. Clinical evidence for the involvement of the subchondral bone in the pathogenesis of OA pain There is a growing body of evidence for the involvement of the subchondral...

leading contributor to disease burden worldwide and affects people of all ages [12]. When the etiology of the pain is unknown, or a person is given an inaccurate diagnosis, unnecessary spinal surgeries or other invasive procedures are...