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or numerically destructed, many diseases continuously develop, finally lead to irreversible interstitial fibrosis. It is not difficult to find that TCs are associated with chronic inflammation and fibrosis. This review mainly discusses...

unilateral ureteral obstruction (UUO)-induced kidney fibrosis in MMP-9 KO mice showed significantly lesser interstitial fibrosis than in wild type mice [69]. Moreover, in the 2000s, researchers started to identify the correlation of MMP...

in idiopathic pulmonary fibrosis and the role of YTHDC1 Idiopathic pulmonary fibrosis (IPF) is characterized by interstitial fibrosis in the lung with unknown causes40,41,42. Advanced aging has been shown to promote IPF43,44,45. For...

lymphoid aggregates and plasma cells infiltrate the alveolar septa and the peribronchial spaces. Interstitial fibrosis is also found [76 -78]. In drug-induced NSIP (Fig. ​1c), interstitial inflammation is typically more homogeneous and...

reactive oxygen species (ROS) production and enhancing pro-fibrotic gene expression, accelerating tubular injury and interstitial fibrosis, both of which contribute to CKD progression [52]. It is also reported that indoxyl sulfate...

BMSC-Exos loaded miR-34c-5p inhibited core fucosylation (CF) by cd81-EGFR complex, thereby improving renal interstitial fibrosis (RIF) [135]. Correspondingly, recent studies also suggest that exosomes from ADSCs ameliorate the...

폐질환 x-ray 하위질병 사르코이드증(sarcoidosis), 특발성 폐섬유증(Idiopathic Pulmonary Fibrosis, IPF), 비특이성 간질성 폐렴(Nonspecific interstitial pneumonia, NSIP), 특발성 기질화 폐렴(Cryptogenic Organizing Pneumonia, COP), 박리성...

뿐 아니라 치료반응과 예후가 다른 7가지 질병으로 분류할 수 있게 되어 이 질병군 전체는 특발성 간질성 폐렴(Idiopathic Interstitial Pneumonia : IIP)이라고 하고, 그 중 가장 예후가 나쁜 경우만을 특발성 폐섬유증(Idiopathic Pulmonary Fibrosis...

are present in only a small proportion of patients with bladder pain syndrome or interstitial cystitis. In the course of the disease, increasing fibrosis of the bladder wall leads to a diminished bladder capacity. Microscopic findings...