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or numerically destructed, many diseases continuously develop, finally lead to irreversible interstitial fibrosis. It is not difficult to find that TCs are associated with chronic inflammation and fibrosis. This review mainly discusses...

lymphoid aggregates and plasma cells infiltrate the alveolar septa and the peribronchial spaces. Interstitial fibrosis is also found [76 -78]. In drug-induced NSIP (Fig. ​1c), interstitial inflammation is typically more homogeneous and...

unilateral ureteral obstruction (UUO)-induced kidney fibrosis in MMP-9 KO mice showed significantly lesser interstitial fibrosis than in wild type mice [69]. Moreover, in the 2000s, researchers started to identify the correlation of MMP...

in idiopathic pulmonary fibrosis and the role of YTHDC1 Idiopathic pulmonary fibrosis (IPF) is characterized by interstitial fibrosis in the lung with unknown causes40,41,42. Advanced aging has been shown to promote IPF43,44,45. For...

reactive oxygen species (ROS) production and enhancing pro-fibrotic gene expression, accelerating tubular injury and interstitial fibrosis, both of which contribute to CKD progression [52]. It is also reported that indoxyl sulfate...

공간(interstitial space)의 체액·단백질·면역세포가 림프(lymph) 로 모여 림프관(lymph vessel) 으로 빠져나갑니다. 관 벽은...부종으로의 전환 림프관이 막히거나 손상되면 간질액이 정체되고, 만성 염증 → 지방 축적(fat cells) + 섬유화(fibrosis...

BMSC-Exos loaded miR-34c-5p inhibited core fucosylation (CF) by cd81-EGFR complex, thereby improving renal interstitial fibrosis (RIF) [135]. Correspondingly, recent studies also suggest that exosomes from ADSCs ameliorate the...

섬유화(Fibrosis)로 인해 부드럽던 결합조직 젤리(GAGs)가 물을 잃고 딱딱한 '갑옷' 처럼 굳어지면, 세포외기질의 물리적 강도(Stiffness)가 수십 배 폭증하게 됩니다. 기계 수용체(Piezo1, Integrin)의 과흥분: 딱딱해진 ECM 환경은 세포막 표면의 기계적...

폐질환 x-ray 하위질병 사르코이드증(sarcoidosis), 특발성 폐섬유증(Idiopathic Pulmonary Fibrosis, IPF), 비특이성 간질성 폐렴(Nonspecific interstitial pneumonia, NSIP), 특발성 기질화 폐렴(Cryptogenic Organizing Pneumonia, COP), 박리성...