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a significant reduction in the incidence of hip and knee replacement in those receiving anti-IL-1β, with a pooled HR of 0.58 (CI 0.42-0.80, p=0.001).65 Some areas of current investigation for disease modification that are being examined...

study comparisons and identify disease-specific alterations. Here, we provide an individual patient data meta-analysis (pooled re-analysis) of all ten available studies that described the gut microbiome in PD through 16S rRNA-gene...

the eMethods in Supplement 1. Statistical Analysis The Review Manager software version 5 (RevMan) was used to calculate pooled mean differences (MDs) with 95% CIs and generate forest plots for pairwise meta-analyses and their...

imputed using the SDs of other similar studies using the prognostic method (ie, calculating the mean of all SDs).19 Pooled means were calculated by adding all the means, multiplied by their sample size, and then dividing this by the sum...