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as glutathione concentrations can determine the response of tumours to therapy, xCT has been suggested as a putative therapeutic target.57,60,61 There is significant demand for glutamate within a proliferating cell not only as an amino...

6, showing that the microbiota can affect α-synucleinopathy as well as neuroinflammation. Thus, the microbiota is a putative therapeutic target and has the potential for developing diagnostic biomarkers. 소개 파킨슨병(PD)은 알츠하이머병...

proteins.59 It has been demonstrated that PARK6, a serine/threonine protein kinase encoded by the PTEN-induced putative kinase 1 gene (PINK1), interacts with parkin to encourage selective autophagy in depolarized mitochondria and...

in the SNpc in mice. The expressions of phosphatase and tensin homolog deleted on chromosome ten (PTEN)-induced putative kinase 1 (PINK1), Parkin, LC3 II and p62 were increased by MPTP, which were blocked in Trx-1 overexpressing mice and...

effects, such as the preservation of the dopaminergic reserves and enhanced dopamine transmission. However, these putative effects have not been directly investigated in humans with PD in vivo. Multimodal neuroimaging enables the...

of J.D. Vance, and his influence was apparent in Vance’s speech to the Republican convention last week, in which the putative vice president described the Republican Party as the “champion of working-class Americans.” On other issues...

who were free to deny its obligation. Because of the dual and potentially conflicting interests of those who are putative parties to the agreement in compelling or resisting its performance, it is impossible to say, solely because they...

methods71,75,76,77. Strains within the type 1A1 phylogroup have increased inflammatory potential based on the presence of putative virulence factors that affect bacterial adhesion and host immune responses78. Historically, vitamin B12...

38,39,40,41,42,43. In general, the absence of an antecedent illness does not exclude a diagnosis of GBS, as putative infections or other immunological stimuli can be subclinical. Vaccines were first linked to GBS in 1976 when a 7.3-fold...