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of the difficulty to gain access to thymic tissue in humans and the lack of in vitro models able to faithfully recapitulate the thymic microenvironment. This review focuses on recent advances in the understanding of human thymus biology...

models of human development and diseases in vitro requires access to large quantities of cells that faithfully recapitulate human biology. Although various primary cell types, such as skin, blood, and cancer cells, can be easily isolated...

been tested in clinical trials with even fewer reaching the clinic3,4. The lack of suitable animal models that could recapitulate the progressive nature of PD for drug screening might be one of the reasons28,29. 1-Methyl-4-phenyl-1,2,3,6...

highlight how organ development is affected by the physical nature of their microenvironment. Research aiming to recapitulate these developmental processes from stem cells in vitro will require sophisticated systems in which forces can...