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myocardial infarction or stroke, is also cytotoxic. Not only does high [Ca2+]i activate proteases and lipases, but it also initiates the mitochondrial permeability transition, an event that permeabilizes the inner mitochondrial membrane...

myocardial infarction to test whether EDTA chelation therapy, high dose vitamin therapy, or both are effective in secondary prevention. The study started in 2003 and was expected to complete in 5 years [14]. However, trials are ongoing...

with renal disease were excluded from the trial95. In contrast, ianalumab, a novel BAFF-targeting antibody that prevents BAFF signalling by blocking BAFFR on B cells96, is worth considering, and this drug has had promising effects in...

myocardial infarction, respectively [71, 73]. Collectively, these evidences suggest that CatB could be a promising therapeutic target for myocarditis. Immune disease As a widely distributed cathepsin in immune cells, CatB is also...