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movement disorder characterized by progressive dopaminergic neurodegeneration in the substantia nigra pars compacta (SNpc) coupled with proteinacious inclusions composed of aggregated α-synuclein1. Clinical dopamine replacement therapy...

in adolescence. This pigmentation is most pronounced in catecholaminergic neurons of the substantia nigra pars compacta (SNpc) and locus coeruleus, leading to a blackened appearance in these regions of aged brains. Loss of NM and...

PD) is characterized by the formation of Lewy body in dopaminergic neurons in the substantia nigra pars compacta (SNpc). Alpha-synuclein (α-syn) is a major component of Lewy body. Autophagy eliminates damaged organelles and abnormal...

well as cognition. It is characterized by i) the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) that project to the dorsal striatum, ii) a massive accumulation of aggregated α-synuclein (α-syn) as the...