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proliferation, invasion, angiogenesis (ERK-STAT3, HIF1 stabilization, Notch 등). MCT ↑, LDHA ↑ → therapeutic target (e.g., LDH inhibitor, MCT blocker). Inflammation: Macrophage polarization, cytokine 조절. Lactate가 pro- or anti...

the invasion. RNA sequencing analysis revealed marked RNA expression changes in mesothelial cells, whereas the changes in EOC cells were minor. Transforming growth factor–β1–stimulated mesothelial cells showed increased invadopodium...

macrophages), stromal cells (fibroblasts), and certain epithelial and tumor cells from homeostasis to active inflammation and tissue remodeling [87,89,90]. This molecular weight-dependent signaling represents a fundamental switch in...

and stromal cells in a chronically activated state. We now have the tools to better understand and translate past observations and to explore our hypothesis that metabolic deviation in synovial cells has a role in early pathogenesis...

and invasion of immune cells [19,20,21,22,23]. Just recently, these calcific deposits were characterized and identified as being nanometer-sized rod-like crystals, mainly composed of hydroxyapatite. A fragmentation of these crystals as...

the invasion of external pathogens (3). Fibroblasts regulate the recruitment and activation of neutrophils in skin diseases through multiple mechanisms, with IL-17 and IL-1 acting upstream in this process. CXCL12+ fibroblasts, located in...

cells, stromal cells, and immune cells (such as T lymphocytes, B lymphocytes, natural killer cells, and tumor-associated macrophages), as well as a dense network of microvessels.93 Apart from the regular components, growing evidence has...

조직검사 결과.... 진단... 방광암 T1G2 3.6cm는 악성상피종양, 나머지 몇개는 양성 종양 grade는 2지만 (grade Ⅱ/Ⅲ with stromal invasion) 침윤기질이 보인다.... 삼성병원의사가 2기는 아니지만 적출직전 단계였고 앞으로 더 두고봐야한다.... 쓰면서...

bladder tumor”, transurethral resection of bladder: • Papillary urothelial carcinoma, grade Ⅰ/ⅠⅠⅠ without stromal invasion • Proper muscle is not included. B. Urinary bladder, “bladder tumor base”, transurethral resection of...