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is handled effectively without evident toxicity during early life. Disease emergence during adulthood coincides temporally with the progressive failure of proteostatic systems and, especially, autophagy at all levels of the pathway...

gapja) signifies that the Sixty-Year Cycle (Yukship-gapja) is also the Three Elements of Heaven, Earth, and Man; temporally, it follows the sequence of Heavenly Element, Earthly Element, and Manly Element. Consequently, in the Upper...

the historical notion that IBD is specific to the ‘Western world’1. Here, we advance the theory that IBD evolves temporally and spatially across four distinct epidemiologic stages. Stage 1 (emergence) is characterized by low incidence...

ecology. We decompose the deep evolutionary history of the shape of the human cortical surface into spatially and temporally conscribed components with highly interpretable functional associations, highlighting the importance of...