cafe

to a cysteine residue on albumin, leaving the other –SH available to chelate metals [39]. DMSA has a large therapeutic window and is the least toxic amongst the dithiol compounds [40]. No significant loss of essential metals like zinc...

detrimental effect on L-DOPA anti-Parkinsonian action, suggesting that such drugs may have a narrow therapeutic window (Bezard et al., 2013). Hence, modulation of the 5-HT system is a promising way to address several manifestations of...

changes and dysfunction play a crucial role in the development of diseases, but they may also provide a therapeutic window for treatment.9,10,14 For example, increases in lysosomal size and capacity facilitate cell metabolism but also...

transporter Pqlc2 (ref.64), which can then drive continued efferocytosis in vitro and in vivo, poses a novel window of therapeutic opportunity. The research on how phagocytes utilize apoptotic cargo to drive their immunological...