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Re: Turning back time with emerging rejuvenation strategies 2022.10.26해당카페글 미리보기
or ‘rejuvenated’ rather than simply delayed. A host of age-associated features have been identified, with a subset being potential drivers of the ageing process (extensively reviewed elsewhere1,2). At the molecular level, ageing...
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Re: The chromatin landscape of cellular senescence 2022.10.15해당카페글 미리보기
active euchromatic A compartments and repressive B compartments in HGPS fibroblasts is significantly lost. A subset (12%) of the regions that could still be assigned to a specific compartment in later passaged HGPS cells changed their...
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Senolytic drugs: from discovery to translation 2022.10.03해당카페글 미리보기
and other factors. For example, endogenous or pharmacological glucocorticoids [37] can attenuate release of a subset of SASP factors, as can rapamycin and metformin [38, 39]. Bacterial toxins such as lipopolysaccharide can exacerbate the...
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Re: Reprogramming the Epigenome With Vitamin C 2022.10.09해당카페글 미리보기
al., 2014). Additional Roles for Vitamin C in Reprogramming Via α-KGDDs Vitamin C enhances the activity of another subset of α-KGDDs, the hypoxia inducible factor (HIF) prolyl hydroxylases (PHs) that regulate the proteasomal...
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Re: The metabolic roots of senescence: mechanisms and opportunities for int 2022.09.30해당카페글 미리보기
to levels observed in the stroma in vivo62. Extension of replicative lifespan and stemness are also observed in a subset of human cell lines, such as human amniotic fluid stem cells64. Additionally, atmospheric O2 levels are required for...
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Re: Re: ER stress and hepatic lipid metabolism 2022.09.30해당카페글 미리보기
ER stress inducers increase de novo lipogenesis and lipid droplet formation in hepatocytes by up-regulating a subset of genes encoding key lipogenic trans-activators and enzymes (Lee et al., 2012). Hepatic lipid homeostasis is controlled...
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Is Mitochondrial Dysfunction a Common Root of Noncommunicable Chronic Disea 2022.10.02해당카페글 미리보기
in the matrix carry out a variety of cellular functions including the synthesis of nucleotides, heme groups, and a subset of essential lipids, among others (42). These organelles are also at the center of cellular life or death decisions...
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Age-related alterations and senescence of mesenchymal stromal cells 2022.10.08해당카페글 미리보기
cells by density gradient centrifugation, followed by expansion of plastic-adherent MSCs. They showed that the MSC subset distribution characterised by expression of CD271 and CD146 correlated with donor age, whereby CD271+CD146– cells...
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β-Hydroxybutyrate - 꼭 읽어야!! 2022.09.22해당카페글 미리보기
inhibition of NF-κB activation (reviewed in Reference 96). More specifically, HCAR activates a neuroprotective subset of macrophages via the production of PGD2 by COX1 (103). The neuroprotective effect of ketogenic diet in a mouse...
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Top 18 New Technology Trends for 2022 2022.08.05해당카페글 미리보기
per year (AI architect) - making it the top new technology trend you must watch out for! Machine Learning the subset of AI, is also being deployed in all kinds of industries, creating a huge demand for skilled professionals. Forrester...